I've not done any long tours on mine. Longest was an evening ride about 400km of highway home from work with less than 10minutes breaks for refueling and "unloading" some water. Most was done at 110km/h
When i ride for fun the speed is lower and i'm not just sitting there for 4 hours ... There are vibrations but not so much that it is a problem for my hands, but the seat on my pony basically forces me in one position. Still considering the expensive option of having it reholstered with a higher and more level top enstead of the rider/passenger edge. Unfortunately the Kahedo seats are pretty expensive but if i was about to go for a loooong ride i would seriously consider it, before spending money on better suspension etc But 460€ can buy you a lot of sheepskins :-)
http://shop.kahedo.com/Seats-Driver/...%7B6%7D31.html